PREVENT Risk Calculator - Nephrology Lectures 2025

🆕 Revolutionary Risk Assessment

PREVENT replaces the Pooled Cohort Equations with contemporary data from 3.28 million participants across 46 diverse cohorts, providing more accurate risk prediction for modern populations.

📝 Patient Information

Age (years): 55

Sex:

Race/Ethnicity:

Social Deprivation Index (ZIP Code-based):

Total Cholesterol (mg/dL): 200

HDL Cholesterol (mg/dL): 50

Systolic Blood Pressure (mmHg): 140

eGFR (mL/min/1.73m²): 90

Risk Factors:

Diabetes

Current Smoking

BP Medications

Statin Therapy

🎯 Risk Assessment Results

10-Year CV Risk

7.2%

Intermediate Risk

💊 Treatment Recommendation

Consider antihypertensive therapy based on Stage 1 HTN and intermediate risk.

📊 Risk Interpretation

<5%: Low risk
5-7.4%: Borderline risk
7.5-19.9%: Intermediate risk
≥20%: High risk

🎯 7.5% Threshold

The 7.5% threshold aligns with statin therapy recommendations, promoting unified cardiovascular risk reduction strategies.

✨ PREVENT Advantages Over Legacy Equations

🕐 Contemporary Data

Based on recent cohorts (2013-2018) vs. Pooled Cohort Equations (1987-2002)

🌍 Diverse Populations

3.28 million participants across 46 cohorts with enhanced racial/ethnic diversity

🏠 Social Determinants

Incorporates ZIP code-based Social Deprivation Index for comprehensive assessment

🫘 Kidney Function

Includes eGFR as independent predictor, enhancing accuracy in CKD patients

📊 PREVENT vs Pooled Cohort Equations Comparison

Feature	PREVENT (2025)	Pooled Cohort Equations (2017)
Data Source	46 contemporary cohorts (2013-2018)	4 historical cohorts (1987-2002)
Sample Size	3.28 million participants	24,626 participants
Social Factors	ZIP code-based Social Deprivation Index	Not included
Kidney Function	eGFR included as predictor	Not included
Modern Therapy	Reflects contemporary treatment patterns	Pre-statin era data
Validation	Validated in multiple external cohorts	Overestimated risk in some populations
Age Range	30-79 years	40-79 years

🎯 Clinical Implementation

✅ When to Use PREVENT

Stage 1 HTN treatment decisions
Shared decision-making discussions
Preventive therapy prioritization
Patient risk communication

⚠️ Limitations

Age restricted to 30-79 years
Not validated in all ethnic groups
Social Deprivation Index availability varies
May not reflect local population characteristics

🧮 PREVENT Risk Calculator