NSAIDs: Check Before You Take Them

Patient education · Visual teaching summary · October 3, 2026

Andrew Bland, MD, FACP, FAAP

Visual summary

Kidney safety starts with checking the whole medicine list, especially during illness.

NSAIDs: Check Before You Take Them. Full text follows below.
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Text version

Read “active ingredients” first

Look for ibuprofen, naproxen, or diclofenac on pain, cold, and arthritis products. Brand names can hide an NSAID. Take a photo of the label and ask the pharmacist before adding it to your usual medicines.

How kidneys are affected

NSAIDs can reduce kidney blood flow, cause fluid retention, raise blood pressure, or trigger kidney inflammation. Risk depends on the person, dose, duration, and current illness.

When risk rises

Kidney disease, dehydration, heart failure, and some medicine combinations increase risk. ACE inhibitors or ARBs plus diuretics deserve particular attention when adding an NSAID.

Ask for a pain plan that fits you

Tell the clinician where the pain is, its cause if known, and your kidney/heart/liver conditions. Ask about physical measures, topical options, or alternatives such as acetaminophen when appropriate. Confirm dose limits and combination ingredients with the pharmacist.

Bring every product

Show your pharmacist or clinician prescription medicines, over-the-counter products, and supplements. A topical product may have lower exposure, but it still needs appropriate use.

Less urine or swelling: call

Contact your team for much less urine, new swelling, vomiting, or dizziness after starting a pain medicine. Bring its name, dose, and dates. Severe breathlessness, chest pain, or fainting: call 911.

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