N5 — Intradialytic Hypotension: Chair-Side Response FRONT
Front · at the chair
When: BP falls or symptoms start during treatment.
Do this
- Trigger: symptoms (dizziness, cramps, nausea, yawning, blurred vision) or systolic BP (SBP) below 90 — or below 100 if pre-dialysis SBP was 160 or higher — with or without symptoms [1].
- Stop UF or set it to minimum. Legs up and head down if tolerated. Recheck BP now.
- Look for red flags (below). If none and BP recovers within 5 minutes, resume UF at a lower rate and recheck every 15 minutes.
- Not recovered: normal saline bolus per standing order; recheck in 5 minutes; repeat once if needed [3].
- Check the machine: temperature per your unit protocol, UF goal and rate, dialysate sodium as ordered.
- Document nadir SBP, time into treatment, fluid given, and UF achieved versus goal.
Call the nephrologist when
- Any red flag: chest pain, new irregular rhythm, confusion, fever or rigors, bleeding, air in the lines, or symptoms in the first minutes of treatment (possible dialyzer reaction — N12: Chair-Side Emergencies).
- BP has not recovered after a second saline bolus, or treatment must end early.
- Hypotension in the first hour of treatment [4].
- A second episode this week, or nadir SBP below 90 in 30% or more of sessions this month [1,2].
- The patient took BP medicines right before treatment and drops repeatedly.
- Recurrent episodes — ask whether cooler dialysate is appropriate under your unit protocol.
Don’t
- Don’t ignore a low BP because the patient “feels fine” [1].
- Don’t give albumin instead of saline [3].
- Don’t restart UF at the rate that caused the drop.
- Don’t give food during treatment to patients who drop often [7].
- Don’t hold all BP medicines on dialysis days without an order — hold only what the nephrologist specifies.
N5 — Intradialytic Hypotension: Chair-Side Response BACK
Back · why, and the evidence
Why
- A nadir SBP below 90 — even without symptoms — had the strongest link to death; symptom-based definitions added nothing [1]. KDIGO: any symptomatic fall or a nadir below 90 should prompt review [2].
- Saline worked as well as 5% albumin in a randomized trial; recurrent hypotension was 36% in both arms [3].
- Hypotension early in the session is not explained by fluid removal and is linked to worse survival [4].
- Frequent intradialytic hypotension is linked to hospitalized mesenteric ischemia (OR 1.82) [5] and new dementia (HR 1.36) [6].
- Eating during treatment caused more symptomatic drops in hypotension-prone patients (13 vs 2 episodes) [7].
Go deeper
References
- Flythe JE, et al. Association of mortality risk with various definitions of intradialytic hypotension. J Am Soc Nephrol. 2015;26:724-734. PubMed 25270068
- Flythe JE, et al. Blood pressure and volume management in dialysis: conclusions from a KDIGO Controversies Conference. Kidney Int. 2020;97:861-876. PubMed 32278617
- Knoll GA, et al. A randomized, controlled trial of albumin versus saline for the treatment of intradialytic hypotension. J Am Soc Nephrol. 2004;15:487-492. PubMed 14747397
- Keane DF, et al. The time of onset of intradialytic hypotension during a hemodialysis session associates with clinical parameters and mortality. Kidney Int. 2021;99:1408-1417. PubMed 33607178
- Seong EY, et al. The relationship between intradialytic hypotension and hospitalized mesenteric ischemia. Clin J Am Soc Nephrol. 2018;13:1517-1525. PubMed 30237215
- Assimon MM, et al. Cumulative exposure to frequent intradialytic hypotension associates with new-onset dementia among elderly hemodialysis patients. Kidney Int Rep. 2019;4:603-606. PubMed 30993235
- Sherman RA, et al. Postprandial blood pressure changes during hemodialysis. Am J Kidney Dis. 1988;12:37-39. PubMed 3389352
Reviewed by Andrew Bland, MD, FACP, FAAP · v1.0 draft 2026-09-26. For education; the physician’s written order and the unit protocol always govern.