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For educational use only — The physician’s written order and the unit protocol always govern
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Dialysis Nursing Reference Card  ·  Maintenance Hemodialysis

N5 — Intradialytic Hypotension: Chair-Side Response

What to do when blood pressure falls during treatment — including when the patient says they feel fine.
Andrew Bland, MD, FACP, FAAP Reviewed September 2026 · v1.0 draft Prints on one sheet, front and back
N5 — Intradialytic Hypotension: Chair-Side Response FRONT
Front · at the chair

When: BP falls or symptoms start during treatment.

Do this

  1. Trigger: symptoms (dizziness, cramps, nausea, yawning, blurred vision) or systolic BP (SBP) below 90 — or below 100 if pre-dialysis SBP was 160 or higher — with or without symptoms [1].
  2. Stop UF or set it to minimum. Legs up and head down if tolerated. Recheck BP now.
  3. Look for red flags (below). If none and BP recovers within 5 minutes, resume UF at a lower rate and recheck every 15 minutes.
  4. Not recovered: normal saline bolus per standing order; recheck in 5 minutes; repeat once if needed [3].
  5. Check the machine: temperature per your unit protocol, UF goal and rate, dialysate sodium as ordered.
  6. Document nadir SBP, time into treatment, fluid given, and UF achieved versus goal.

Call the nephrologist when

  • Any red flag: chest pain, new irregular rhythm, confusion, fever or rigors, bleeding, air in the lines, or symptoms in the first minutes of treatment (possible dialyzer reaction — N12: Chair-Side Emergencies).
  • BP has not recovered after a second saline bolus, or treatment must end early.
  • Hypotension in the first hour of treatment [4].
  • A second episode this week, or nadir SBP below 90 in 30% or more of sessions this month [1,2].
  • The patient took BP medicines right before treatment and drops repeatedly.
  • Recurrent episodes — ask whether cooler dialysate is appropriate under your unit protocol.

Don’t

  • Don’t ignore a low BP because the patient “feels fine” [1].
  • Don’t give albumin instead of saline [3].
  • Don’t restart UF at the rate that caused the drop.
  • Don’t give food during treatment to patients who drop often [7].
  • Don’t hold all BP medicines on dialysis days without an order — hold only what the nephrologist specifies.
N5 — Intradialytic Hypotension: Chair-Side Response BACK
Back · why, and the evidence

Why

  1. A nadir SBP below 90 — even without symptoms — had the strongest link to death; symptom-based definitions added nothing [1]. KDIGO: any symptomatic fall or a nadir below 90 should prompt review [2].
  2. Saline worked as well as 5% albumin in a randomized trial; recurrent hypotension was 36% in both arms [3].
  3. Hypotension early in the session is not explained by fluid removal and is linked to worse survival [4].
  4. Frequent intradialytic hypotension is linked to hospitalized mesenteric ischemia (OR 1.82) [5] and new dementia (HR 1.36) [6].
  5. Eating during treatment caused more symptomatic drops in hypotension-prone patients (13 vs 2 episodes) [7].

Go deeper

References

  1. Flythe JE, et al. Association of mortality risk with various definitions of intradialytic hypotension. J Am Soc Nephrol. 2015;26:724-734. PubMed 25270068
  2. Flythe JE, et al. Blood pressure and volume management in dialysis: conclusions from a KDIGO Controversies Conference. Kidney Int. 2020;97:861-876. PubMed 32278617
  3. Knoll GA, et al. A randomized, controlled trial of albumin versus saline for the treatment of intradialytic hypotension. J Am Soc Nephrol. 2004;15:487-492. PubMed 14747397
  4. Keane DF, et al. The time of onset of intradialytic hypotension during a hemodialysis session associates with clinical parameters and mortality. Kidney Int. 2021;99:1408-1417. PubMed 33607178
  5. Seong EY, et al. The relationship between intradialytic hypotension and hospitalized mesenteric ischemia. Clin J Am Soc Nephrol. 2018;13:1517-1525. PubMed 30237215
  6. Assimon MM, et al. Cumulative exposure to frequent intradialytic hypotension associates with new-onset dementia among elderly hemodialysis patients. Kidney Int Rep. 2019;4:603-606. PubMed 30993235
  7. Sherman RA, et al. Postprandial blood pressure changes during hemodialysis. Am J Kidney Dis. 1988;12:37-39. PubMed 3389352

Reviewed by Andrew Bland, MD, FACP, FAAP · v1.0 draft 2026-09-26. For education; the physician’s written order and the unit protocol always govern.