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For educational use only — The physician’s written order and the unit protocol always govern
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Dialysis Nursing Reference Card  ·  Maintenance Hemodialysis

N8 — Catheter Care and Infection Bundle

Every connection and disconnection is an infection-control procedure. Do the whole bundle, every time.
Andrew Bland, MD, FACP, FAAP Reviewed September 2026 · v1.0 draft Prints on one sheet, front and back
N8 — Catheter Care and Infection Bundle FRONT
Front · at the chair

When: every catheter connection, disconnection, and dressing change.

Do this

  1. Check first: exit site, tunnel, dressing, and the patient (fever, chills) at every session [6].
  2. Masks for patient and staff; the patient turns the head away and limits talking.
  3. Hand hygiene, gloves, and a clean field under the catheter limbs.
  4. Clamp before opening. Confirm both limbs are clamped before any cap comes off.
  5. Scrub the hub with chlorhexidine (povidone-iodine if intolerant) every time the catheter is accessed or disconnected [6].
  6. Aspirate 2–5 mL of blood and lock from each lumen before connecting, one lumen at a time [6]. A taurolidine/heparin lock must always be aspirated and discarded [7].
  7. Dressing change: alcohol-based chlorhexidine (more than 0.5%) on the skin; exit-site ointment per your unit protocol after checking catheter compatibility; change at least weekly and whenever wet or soiled [6].
  8. Lock: saline flush, the prescribed lock at your protocol’s volume, clamp, and a new sterile cap every time.
  9. Can’t reach the prescribed blood flow? That is catheter dysfunction: check position, clamps, and flush, then follow the thrombolytic protocol.

Call the nephrologist when

  • Immediately: fever, rigors, hypotension, or confusion during or after dialysis. Draw two blood cultures (catheter hub and dialysis circuit) before the first antibiotic dose [6].
  • Same day: pus or spreading redness at the exit site; tenderness or redness along the tunnel; the cuff is visible or the catheter looks longer.
  • Before the next session: dysfunction not fixed by bedside maneuvers or one alteplase dwell.
  • Monthly at rounds: the patient still has a catheter — ask what the permanent-access plan is.

Don’t

  • Don’t leave a lumen open to air — clamp first, cap every time.
  • Don’t infuse or flush the lock into the patient; aspirate it.
  • Don’t use the catheter for blood draws or medications outside dialysis unless ordered.
  • Don’t start antibiotics before cultures [6].
  • Don’t use taurolidine/heparin in a patient with heparin-induced thrombocytopenia or pork allergy [7].
N8 — Catheter Care and Infection Bundle BACK
Back · why, and the evidence

Why

  1. Catheter patients have about 8 times the bloodstream infection rate of fistula patients (2.16 vs 0.26 per 100 patient-months) [1].
  2. Units that implemented the CDC bundle (chlorhexidine, audits, competency, feedback) cut access-related bloodstream infections by 54% [2].
  3. Chlorhexidine skin antisepsis roughly halved catheter-related bloodstream infection compared with povidone-iodine (RR 0.49) [3].
  4. A once-weekly alteplase lock cut catheter malfunction from 34.8% to 20.0% and bacteremia from 13.0% to 4.5% over 6 months [4].
  5. A taurolidine/heparin lock cut catheter-related bloodstream infection from 8.0% to 2.3% (NNT 18) in LOCK IT-100 [5,7].

Go deeper

References

  1. Nguyen DB, et al. National Healthcare Safety Network (NHSN) Dialysis Event Surveillance Report for 2014. Clin J Am Soc Nephrol. 2017;12:1139-1146. PubMed 28663227
  2. Patel PR, et al. Bloodstream infection rates in outpatient hemodialysis facilities participating in a collaborative prevention effort. Am J Kidney Dis. 2013;62:322-330. PubMed 23676763
  3. Chaiyakunapruk N, et al. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med. 2002;136:792-801. PubMed 12044127
  4. Hemmelgarn BR, et al. Prevention of dialysis catheter malfunction with recombinant tissue plasminogen activator. N Engl J Med. 2011;364:303-312. PubMed 21268722
  5. Agarwal AK, et al. Taurolidine/heparin lock solution and catheter-related bloodstream infection in hemodialysis (LOCK IT-100). Clin J Am Soc Nephrol. 2023;18:1446-1455. PubMed 37678222
  6. Lok CE, et al. KDOQI clinical practice guideline for vascular access: 2019 update. Am J Kidney Dis. 2020;75(4 Suppl 2):S1-S164. PubMed 32778223
  7. DEFENCATH (taurolidine and heparin) catheter lock solution, prescribing information. CorMedix Inc.; DailyMed. dailymed.nlm.nih.gov

Reviewed by Andrew Bland, MD, FACP, FAAP · v1.0 draft 2026-09-26. For education; the physician’s written order and the unit protocol always govern.